Company Profile

Legend Biotech USA

Company Overview

Legend Biotech is a global clinical-stage biopharmaceutical company engaged in the discovery and development of novel cell therapies for oncology and other indications. Our team of over 1,000 employees across the United States, China and Europe, along with our differentiated technology, global development, and manufacturing strategies and expertise, provide us with the strong potential to discover, develop, and manufacture cutting edge cell therapies for patients in need.

Company History

Legend Biotech was founded as an early-stage cell therapy company in 2014. The company was the brainchild of visionary scientists who recognized that antibody-based therapeutics could potentially treat disease and possessed the backgrounds in immunology and gene editing to take the leap.

For two years, Legend Biotech, then known as the “Legend Project,” operated in a room the size of a freight elevator, with the goal of creating a cell therapy for multiple myeloma, a hematological cancer that often relapses and can become refractory. The team produced nanobodies for single-domain antibody drugs and ultimately extended the half-life of the nanobodies with proprietary technologies.

In 2015, Legend’s scientists focused on research for chimeric antigen-receptor T-cells (CAR-T) targeting the BCMA protein, making the biotech one of the first companies in the world to engineer CAR-T cells for the BCMA protein. In 2016, investigator-initiated trials began in China.

In 2017, data from the trials were presented at the American Society for Clinical Oncology (ASCO), which led to a partnership with biopharmaceutical company Janssen Biotech, Inc. to co-develop the anti-BCMA CAR-T, ciltacabtagene autoleucel (cilta-cel). Applications seeking approval of cilta-cel for the treatment of patients with RRMM are currently under regulatory review by several health authorities around the world. CARVYKTI™ (ciltacabtagene autoleucel) was approved by the U.S. Food and Drug Administration in February 2022 and received conditional marketing approval from the European Medicines Agency in May 2022.

Today Legend Biotech is a global, commercial-stage company driven by a passion for patients. We continue to build our pipeline of cell therapy platforms, which includes CAR-T, CAR-NK, CAR-?? T and non-gene-editing CAR technologies.

Our goal is to bring hope and opportunity to patients and their families by continuing to explore unique technologies.

Positions Available
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  • 1 day ago

    Project Manager, External Engagement (Contractor)

    Legend Biotech USA - Bridgewater, NJ, United States
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    Legend Biotech is seeking a Project Manager, External Engagement (Contractor)as part of the Commercial team based in Bridgewater, NJ.Role OverviewReporting to Executive Director, External Engagement, the Project Manager will run and manage multiple projects in a proactive manner. Leverage project management tools and processes, including detailed timelines, milestones and daily tracking to ensure projects are delivered to company goals and commitments. Be prepared to report on project progress ...

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  • 19 days ago

    CMC Project Management Intern

    Legend Biotech USA - Somerset, NJ, United States
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    Legend Biotech is seeking a CMC Project Management Intern as part of the Technical Developmentteam based in Somerset, NJ.Role OverviewLegend Biotech is seeking an Intern as part of the CMC Project Management team based in Somerset, NJ}to support CMC (Chemistry, Manufacturing, and Controls) activities for our cell therapy programs. This role provides exposure to process development, analytical development, manufacturing, and quality control within a biotech environment. The intern will work ...

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